Elsevier TDMBechmann, NicoleBerger, IlonaSteenblock, CharlotteBornstein, Stefan R2025-06-142025-06-142021-05-010303-720710.1016/j.mce.2021.111258https://trapdev.rcub.bg.ac.rs/handle/123456789/412624The mammalian adrenal gland is composed of two distinct tissue types in a bidirectional connection, the catecholamine-producing medulla derived from the neural crest and the mesoderm-derived cortex producing steroids. The medulla mainly consists of chromaffin cells derived from multipotent nerve-associated descendants of Schwann cell precursors. Already during adrenal organogenesis, close interactions between cortex and medulla are necessary for proper differentiation and morphogenesis of the gland. Moreover, communication between the cortex and the medulla ensures a regular function of the adult adrenal. In tumor development, interfaces between the two parts are also common. Here, we summarize the development of the mammalian adrenal medulla and the current understanding of the cortical-medullary interactions under development and in health and disease.CLOSED5701303 BiochemistryChromaffin CellsInteractions10265 Clinic for Endocrinology and Diabetology610610 Medicine & healthCell DifferentiationStem cellsDevelopmentMedulla1310 EndocrinologyCatecholaminesAdrenal MedullaNeural CrestCortex1312 Molecular BiologyAdrenal CortexAnimalsHumansAdrenalPathologiespublication0303 health sciences03 medical and health sciencesdoi_dedup___33798635