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Abstract
Inhaled adenosine receptor agonists induce bronchoconstriction and inflammation in asthma and are used as bronchial challenge agents for the diagnosis of asthma and in respiratory drug development. Recently developed dry powder aerosols of adenosine have several advantages over nebulised adenosine 5'-monophosphate (AMP) as bronchial challenge agents. However, reverse translation of...
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Keywords
Male , Adenosine 5′-monophosphate , INHALATION EXPOSURES , Adenosine , Bronchoconstriction , Guinea Pigs , 610 , Drug development , Adenosine 5 '-monophosphate , Drug development Dry powder inhalation , RESPONSIVENESS , Purinergic P1 Receptor Agonists , Respiratory Hypersensitivity , Animals , Particle Size , Lung , Aerosols , Nebulizers and Vaporizers , ADENOSINE , Asthma , Adenosine Monophosphate , Disease Models, Animal , INTRATRACHEAL INSTILLATION , ASTHMA , Original Article , Powders , LUNG